Karen Duff, University College London, UK

Karen Duff

Karen Duff is the Centre Director of the UK Dementia Research Institute at University College London.. After receiving her PhD from professor Sydney Brenner’s department at the University of Cambridge, she did postdoctoral research with professor Alison Goate at University College London and with professor John Hardy at the University of South Florida. She was an assistant professor at the University of South Florida (1993–96), associate professor at Mayo Clinic Jacksonville (1996–98), professor at the New York University Nathan Kline Institute (1998–2006), and deputy director of the Taub Institute at Columbia University (2006–19). Over the past 27 years, she has created several transgenic mouse models for Alzheimer’s disease, frontotemporal dementia, and other dementias to explore disease mechanisms and test therapeutic approaches for these conditions. Her current work explores the mechanisms involved in the spread of pathogenic proteins within the brain, the role of ApoE4 in Alzheimer's disease pathogenesis, and the role and therapeutic potential of autophagy and proteasome-mediated clearance to remove pathological proteins. Duff has published more than 130 peer-reviewed research articles and received several prizes, including the Potemkin Prize in 2006.

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